The choice is physio-logical
Non Avian Derived {NAD}
Non Heat Degraded {NHD}
Sodium hyaluronate
Professional healthcare
HA viscosupplementation references

This section provides a selection of references and publications on visco-supplementation. You will find official guidelines, meta-analysis, reviews and articles on this treatment modality.
 
GUIDELINES

EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)
Jordan & Al., 2003


 
  Recommendations for the Medical Management of Osteoarthritis of the Hip and Knee
American College of Rheumatology, 2000
 
  OARSI 2008 recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines
 
 
META-ANALYSIS AND REVIEWS

Viscosupplementation for the treatment of osteoarthritis of the knee - The Cochrane collaboration (Abstract)
Bellamy & Al., 2005
 
   Hylan versus hyaluronic acid for osteoarthitis of the knee: a systematic review and meta-analysis
Reichenbach & Al., 2007
 
  Intra-articular injections for osteoarthritis of the knee
Neustadt, 2006

 
  Intra-articular Hyaluronic Acid (Viscosupplementation) for Knee Osteoarthritis
Canadian Agency for Drugs and Technologies in Health, 2006

 
  Therapeutic Effects of Hyaluronic Acid on Osteoarthritis of the Knee. A Meta-Analysis of Randomized Controlled Trials
Chen-Ti Wang & Al., 2004.

 
 
MODE OF ACTION

The Physical properties of Synovial Fluid and the Special Role of Hyaluronic Acid
Balazs, 1974

 
  Hyaluronan: its nature, distribution, functions and turnover
Fraser & Al., 1997

 
 
Hyaluronans: Is clinical effectiveness dependent on molecular weight?
Vitanzo & Al., 2006

 
  Potential Mechanism of Action of Intra-articular Hyaluronan Therapy in Osteoarthritis: Are the effects Molecular Weight Dependent?
Ghosh, 2002

 
 
CLINICAL DATA

Potential Structural effects


Arthroscopic evaluation of potential structure modifying activity of hyaluronan (Hyalgan) in osteoarthritis of the knee
Listrat & Al., 1997

 
  Intra-articular hyaluronic acid in the treatment of osteoarthritis of the knee: Clinical and morphological study
Frizziero & Al., 1998

 
 
Role of molecular weight


Efficacy and Safety of Intraarticular Hylan or Hyaluronic Acids for Osteoarthritis of the Knee
Juni & Al., 2007

 
  Comparison between high and low molecular weight hyaluronates in knee osteoarthritis patients: open-label, randomized, multicentre clinical trial 
PB Lee & Al., 2006